Figure 4 Reciprocal-hemizygosity analysis. a, Comparison between reciprocal YFG1 hemizygotes (a generic gene name). Each block represents a gene. Each hemizygote carries only a single allele of YFG1 but has an otherwise hybrid diploid genome. Two different dominant drug markers (open boxes) distinguish between competing reciprocal strains. b, Reciprocal-hemizygosity analysis of MKT1, END3 and RHO2 at 41 °C. For each gene pair, 12 measurements (n = 12) were taken to calculate the growth mean (c.f.u. ml^-1) and s.e.m. c, Htg contributions of MKT1-145, END3-288 and RHO2-145 alleles (n = 12). d, Role of S288c-derived alleles in heterosis. Competitions between YAG040 (Htg⁺ YJM145 background) and the hybrids, XHS122 (END3-145/D) and XHS123 (YJM145/S288c) (n = 6). e, Role of YJM145-derived alleles in heterosis. Competitions between S1029 (Htg^- S288c background) and the hybrids, XHS119 (MKT-288/D) and XHS123 (n = 6).

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