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Acknowledgements: We thank N. Risch, E. Mignot and K. White for helpful advice. This work was supported by the NIH (J.H.M., P.J.O, and R.W.D). L.M.S is a Howard Hughes Medical Institute predoctoral fellow. Correspondence and requests for materials should be addressed to J.H.M. (e-mail: mccus001@mc.duke.edu) or R.W.D. (e-mail: dbowe@sequence.stanford.edu).

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